Can you use statins? Did you use it correctly?

      Can you use statins?

　　It is well known that hyperlipidemia is an important factor in the development of atherosclerosis.

　　Atherosclerosis is one of the fundamental causes of coronary artery disease, cerebrovascular disease and other diseases.

　　Statins are the main force in the current lipid regulation drugs.

　　Like rosuvastatin, atorvastatin, simvastatin, fluvastatin, fluvastatin, lovastatin, pivastatin and pravastatin, they all affect the synthesis of cholesterol.

　　However, due to different structures, there are also many differences.

　　Resuvastatin and atorvastatin have a long time of action in the body (half life is about 20 hours) and are not affected by food, so they can be taken at any time of the day.

　　Rivastatin is mainly metabolized through the kidney. People with renal insufficiency should pay attention to it.

　　Atorvastatin is mainly metabolized and eliminated in the liver, so patients with a history of liver disease should use it with caution.

　　Fluvastatin, Pivastatin and Pravastatin have a short acting time in the body (half-life of 1.5-4 hours), so they should be taken before sleep (cholesterol synthesis is mainly carried out at night).

　　Pravastatin can be considered in patients with abnormal liver and kidney functions; For those with high blood glucose, we can fully consider using pivastatin, but those with abnormal liver function indicators should be cautious.

　　Simvastatin and lovastatin, because of their lipophilic chemical structure, food is conducive to their absorption and utilization, and their short working time in the body (half-life 1-4 hours), are best taken with meals.

　　Because it is mainly metabolized and eliminated in the liver, the use of liver history should be cautious.

　　The dosage of statins should be considered according to health status and blood lipid level.

　　At the same time, when using statins, regularly check blood lipids, blood glucose, liver function, renal function, muscle enzymes, etc., so as to timely understand the role of lipid regulation and adverse reactions.

　　In case of muscle pain, obvious abnormality of liver and kidney, and increase of muscle enzyme during application, drug withdrawal or dressing change can be considered.

　　In some patients, triglycerides are elevated, which can focus on lifestyle changes, supplemented by better drug treatment.

Shandong Zhushi Pharmaceutical Group Co., Ltd., founded in 2003, has more than 5000 registered employees. After years of development, it has developed into a diversified industrial cluster integrating medical devices, polymers, cosmetics, health food, daily necessities and biological reagent production, enterprise management consulting and training, real estate economy, pharmaceutical transportation, pharmaceutical printing, etc.

Adhering to the concept of life, health and happiness, the Group provides you with full chain health services.

HOT

NEW